cardiorenal syndrome造句

• They defined the cardiorenal syndrome as a pathophysiological condition in which combined heart and kidney dysfunction amplifies progression of failure of the individual organ, by inducing similar pathophysiological mechanisms.
• "' Cardiorenal syndrome ( CRS ) "'is an umbrella term used in the medical field that defines disorders of the heart and kidneys whereby  acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other.
• Braam et al . argue that classifying the CRS based on the order in which the organs are affected and the timeframe ( acute vs chronic ) is too simplistic and without a mechanistic classification it is difficult to study CRS . They view the cardiorenal syndrome in a more holistic, integrative manner.
• Experimentally, the membrane potential at which the channels show no net movement of ions at a given chloride concentration drops significantly with the mutation, indicating altered function in situ . his manifests as a chronic salt wasting disorder similar to Bartter syndrome, as sodium reabsorption is coupled with chloride reabsorption . he salt loss results in a decrease blood volume and consequently hyperreninemia leading ( via the end product angiotensin II and aldosterone ) to increased vascular tone, heart rate, water reabsorption, and blood pressure, collectively referred to as cardiorenal syndrome.